| 特点 | |
|---|---|
| 特性 | 识别标签：DXD，BIOTIN 应用：Elisa/WB | 优势 | 另有大包装100UG和1MG出售 |
Biotin-conjugated anti-Dxd mAb
Background
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor. Dxd is cytotoxic to human cancer
cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control
IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression).
Biotin-anti-DXD-antibody is a conjugation product of Biotin and anti-DXD-antibody. It can be used in PK, PD
analysis and ELISA.
Specificity: Specifically recognizes the target-DXD
Source: Mouse, Monoclonal Clone #13
Isotype: IgG1
Conjugation: Biotin
Concentration: 1.0 mg/ml
Tested applications: ELISA
Recommended dilution: 1:1000 - 1:5000(optimal dilutions should be determined by the end use.)
Storage Buffer: PBS Buffer, pH7.4
Storage: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Stable for 2
years from date of receipt. Aliquot to avoid repeated freezing and thawing.
* Please note: FOR RESEARCH USE ONLY
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